The UCSF-led Sjögren’s International Collaborative Clinical Alliance (SICCA) held an Investigators’ Meeting in Washington DC on April 26, 2006. SICCA includes five Research Groups, located in Beijing , Buenos Aires , Copenhagen , Kanazawa and San Francisco . The project is directed by UCSF professors Troy Daniels and John Greenspan and is supported by a five year NIDCR/NEI grant (now in the third year). The Alliance is working toward establishing standardized diagnostic criteria for this disease and building an international registry of uniform clinical data and biospecimens that are available to scientists all over the world, with the intent of furthering the understanding of Sjögren’s syndrome and ultimately of treating it. The investigators include dentists (oral medicine and oral pathology), ophthalmologists, rheumatologists and statisticians; a collaborative effort in the best meaning of the term.